Endocrine Abstracts

Introduction: Graves’ disease (GD), similarly to most autoimmune disease, is triggered by environmental factors in genetically predisposed individuals. Particular HLA alleles increase or decrease GD risk. We have recently demonstrated novel, previously not reported association between a presence of alleles HLA-B*39:06, -B*37:01, -C*14:02, -C*03:02, -C*17:01, -DRB1*14:01 and GD. These alleles are independent risk factors, with no linkage disequilibrium with other,...

Introduction: Subacute thyroiditis is a thyroid inflammatory disease, triggered mainly by viral factors in genetically susceptible individuals. Up to 2020, only HLA-B*35 was confirmed as SAT-related. However, obviously in HLA-B*35-negative patients, some other genetic background occurs. Material and Methods: We performed HLA-typing using high resolution NGS method in different groups of patients with SAT and demonstrated the new association between HLA a...